Disruption of mgrB gene by ISkpn14 sourced from a blaKPC−2 carrying plasmid mediating polymyxin resistance against carbapenem-resistant Klebsiella pneumoniae during treatment: study on the underlying mechanisms
This study provides direct experimental evidence that the ISkpn14 element causing mgrB inactivation and polymyxin resistance in K. pneumoniae originates from bla<sub>KPC-2</sub>-carrying plasmids. Minocycline exposure will accelerate the evolution of polymyxin resistance. Understanding the dynamics of IS transposition and its association with antibiotic exposure is crucial for developing effective strategies to reduce the emergence of polymyxin resistance in CRKP.
Authors
- Jiankang Zhao (ORCID: https://orcid.org/0000-0002-2758-2034)
- Zichen Lei
- Hua Yang (ORCID: https://orcid.org/0000-0001-5012-0594)
- Yongli Wu (ORCID: https://orcid.org/0000-0001-9774-453X)
- Xinrui Yang (ORCID: https://orcid.org/0000-0002-2135-3425)
- Binghuai Lu (ORCID: https://orcid.org/0000-0003-3510-2747)
- Chen Li (ORCID: https://orcid.org/0000-0002-1847-754X)
- Bin Cao (ORCID: https://orcid.org/0000-0001-6991-0350)
- Feilong Zhang (ORCID: https://orcid.org/0000-0002-9281-0742)
- Yulin Zhang (ORCID: https://orcid.org/0000-0002-3231-953X)
- Xinmeng Liu
- Ziyao Li (ORCID: https://orcid.org/0000-0001-7346-2976)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Steinbeis Foundation (DE)
- National Clinical Research Center for Digestive Diseases (CN)
- Center for Life Sciences (CN)
- Xiangyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s12866-024-03572-2
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.51