Radical-Initiated Dearomative Annulation of Tryptamine-Derived Isocyanides: Selective Synthesis of CF<sub>3</sub>-Substituted β-Aza-spiroindolines and β-Carbolines
A mild approach for synthesizing CF<sub>3</sub>-substituted β-aza-spiroindolines and β-carbolines from tryptamine-derived isocyanides via site-selective radical annulations has been reported. The crucial role of C2 substituents in the selective annulation process has been clarified. The approach shows good generality and practical applicability, highlighting its effectiveness and versatility.
Authors
- Xiaoping Xu (ORCID: https://orcid.org/0000-0001-8031-3688)
- Luo-Rong Yuan
- You Zi (ORCID: https://orcid.org/0000-0002-6960-2646)
- Shun‐Jun Ji (ORCID: https://orcid.org/0000-0002-4299-3528)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Laboratoire de Synthèse Organique (FR)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1021/acs.joc.4c02302
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions