Oral-gut microbiome interactions in advanced cirrhosis: characterisation of pathogenic enterotypes and salivatypes, virulence factors and antimicrobial resistance
This research underscores the crucial role of microbiome alterations in the progression of cirrhosis in an era of escalating multidrug resistant infections, highlighting the association and potential impact of increased oral-gut microbial overlap, virulence factors, and antimicrobial resistance genes on clinical outcomes. These findings are particularly significant for patients with decompensated cirrhosis and acute-on-chronic liver failure, as they reveal the intricate relationship between microbiome alterations and cirrhosis complications. This is relevant in the context of multidrug-resistant organisms and reduced oral-gut microbial diversity that exacerbate cirrhosis severity, drive hepatic decompensation and complicate treatment. For practical applications, these insights could guide the development of targeted microbiome-based therapeutics and personalised antimicrobial regimens for patients with cirrhosis to mitigate infectious complications and improve clinical outcomes.
Authors
- Neelu Begum (ORCID: https://orcid.org/0000-0003-4408-8940)
- Lindsey Edwards (ORCID: https://orcid.org/0000-0002-8222-4555)
- Debbie L. Shawcross (ORCID: https://orcid.org/0000-0001-6133-4619)
- Adil Mardinoğlu (ORCID: https://orcid.org/0000-0002-4254-6090)
- David L. Moyes (ORCID: https://orcid.org/0000-0002-1657-918X)
- Shilpa Chokshi (ORCID: https://orcid.org/0000-0003-1735-8538)
- Haizhuang Cai
- Merianne Mohamad (ORCID: https://orcid.org/0000-0001-7520-4911)
- Gordon Proctor (ORCID: https://orcid.org/0000-0002-5684-841X)
- Azadeh Harzandi
- Marilena Stamouli (ORCID: https://orcid.org/0000-0003-2029-9161)
- Ane Zamalloa
- Mathias Uhlén (ORCID: https://orcid.org/0000-0002-4858-8056)
- Bethlehem Arefaine (ORCID: https://orcid.org/0000-0001-9812-9168)
- Mark McPhail (ORCID: https://orcid.org/0000-0001-5449-2424)
- Vishal Patel (ORCID: https://orcid.org/0000-0001-6616-3628)
- Sunjae Lee (ORCID: https://orcid.org/0000-0002-6428-5936)
- Michael A. Curtis (ORCID: https://orcid.org/0000-0002-1563-9953)
- Elizabeth A. Witherden (ORCID: https://orcid.org/0000-0002-7391-9371)
- Saeed Shoaie (ORCID: https://orcid.org/0000-0001-5834-4533)
- Roger Williams (ORCID: https://orcid.org/0009-0009-4262-8692)
Institutions
- King's College London (GB)
- Science for Life Laboratory (SE)
- Gwangju Institute of Science and Technology (KR)
- King's College Hospital NHS Foundation Trust (GB)
- Kings Health Partners (GB)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1016/j.jhep.2024.09.046
- Citations
- 30
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 11.08
Funders
- King's College Hospital NHS Foundation Trust
- Foundation for Liver Research
- King’s College Hospital Charity
- National Institute for Health and Care Research
- King's College London
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Knut och Alice Wallenbergs Stiftelse
- Kungliga Tekniska Högskolan
- Vetenskapsrådet
- Science for Life Laboratory
- Engineering and Physical Sciences Research Council
- Korea National Institute of Health
- Uppsala Multidisciplinary Center for Advanced Computational Science