Aspergillus fumigatus sensu stricto genetic diversity from cystic fibrosis patients
We aimed to access the genetic diversity of Apergillus fumigatus strains obtained from cystic fibrosis (CF) patients from southern Brazil. A. fumigatus sensu stricto isolates from respiratory clinical specimens were genotyped by microsatellite markers and azole resistance was evaluated by azole-agar screening. Twenty-seven isolates from twenty-seven patients showed a high genetic diversity, with the differentiation of 25 different genotypes (25 unique and one common to two isolates). All isolates were susceptible to the azoles tested. We believe that prospectively monitoring A. fumigatus genetic diversity is essential to identify interpatient transmission and outbreaks, as is the identification of resistant strains.
Authors
- Melissa Orzechowski Xavier (ORCID: https://orcid.org/0000-0002-3883-0080)
- Cecília Bittencourt Severo (ORCID: https://orcid.org/0000-0003-0321-4330)
- David A. Stevens (ORCID: https://orcid.org/0000-0002-5861-5716)
- Raquel Sabino (ORCID: https://orcid.org/0000-0001-6585-7775)
- Aryse Melo (ORCID: https://orcid.org/0000-0002-6655-8715)
- Fernando Azevedo Faria (ORCID: https://orcid.org/0000-0002-7339-400X)
- Valério Rodrigues Aquino
- Mariana Rodrigues Trápaga (ORCID: https://orcid.org/0000-0003-1407-8135)
- Cristina Veríssimo (ORCID: https://orcid.org/0000-0002-1169-252X)
- Vanice Rodrigues Poester (ORCID: https://orcid.org/0000-0001-7121-3861)
Institutions
- Universidade Federal do Rio Grande (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- University of Lisbon (PT)
- Hospital de Clínicas de Porto Alegre (BR)
- Instituto de Pesquisas da Marinha (BR)
- Stanford Medicine (US)
- National Institute of Health Dr. Ricardo Jorge (PT)
- Bernhard Nocht Institute for Tropical Medicine (DE)
- Stanford University (US)
Publication Details
- Journal
- International Journal of Medical Microbiology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1016/j.ijmm.2024.151639
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior