P2X4 receptor mediates macrophage infiltration leading to endometriotic cyst epithelium proliferation and hyperalgesia in mouse model
These results indicate unknown pathophysiological roles of P2X4R expressed in local macrophages at the injury site of endometriosis and in the vagina, suggesting the potential therapeutic effects of orally administered P2X4R inhibitors for alleviating the symptoms of endometriosis.
Authors
- Kazuomi Nakamura (ORCID: https://orcid.org/0000-0003-3532-2395)
- Yukihiro Azuma (ORCID: https://orcid.org/0000-0001-5755-1442)
- Takeshi Y. Hiyama (ORCID: https://orcid.org/0000-0001-8612-8707)
- Yuki Yoshimura (ORCID: https://orcid.org/0000-0001-7092-6683)
- Fuminori Taniguchi (ORCID: https://orcid.org/0000-0001-6922-0632)
- Tasuku Harada (ORCID: https://orcid.org/0000-0002-1492-7275)
- Ikumi Wada
- Misaki Inoue
- Shanshan Xu (ORCID: https://orcid.org/0000-0001-7652-8774)
- Hiroki Nagata (ORCID: https://orcid.org/0009-0007-9052-1502)
Institutions
- Tottori University Hospital (JP)
- Tottori University (JP)
Publication Details
- Journal
- F&S Science
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1016/j.xfss.2024.10.007
- Citations
- 1
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Japan Agency for Medical Research and Development
- Kaken Pharmaceutical