Lhx6 deficiency causes human embryonic palatal mesenchymal cell mitophagy dysfunction in cleft palate
Lhx6 is essential for mitochondrial homeostasis via tuning PINK1/Parkin-mediated mitophagy and MAPK signaling pathways. Downregulation of Lhx6 by RA transcriptionally disturbs the mitochondrial homeostasis, which in turn leads to the proliferation and migration defect in HEPM cells, ultimately causing the cleft palate.
Authors
- Bingyan Guo (ORCID: https://orcid.org/0000-0002-6625-229X)
- Yungshan Teng
- Delan Huang (ORCID: https://orcid.org/0000-0003-3763-6195)
- Xin Chen (ORCID: https://orcid.org/0000-0001-9646-080X)
- Danying Chen (ORCID: https://orcid.org/0000-0001-9730-1536)
- Wenfeng Li (ORCID: https://orcid.org/0000-0002-6992-0505)
- Yuqing Guo (ORCID: https://orcid.org/0009-0003-1738-0353)
- Ruoyu Li (ORCID: https://orcid.org/0000-0003-1451-3598)
- Runze Li (ORCID: https://orcid.org/0000-0003-2543-3032)
- Haotian Luo
- Chen Zhou (ORCID: https://orcid.org/0000-0003-2277-8553)
- Ying Qing (ORCID: https://orcid.org/0000-0002-9551-8907)
- Weicai Wang (ORCID: https://orcid.org/0000-0002-0601-2497)
- Hio Cheng Ieong
- Yang Cao (ORCID: https://orcid.org/0000-0003-3111-5751)
Institutions
- Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s10020-024-00960-2
- Citations
- 7
- Primary Topic
- Cleft Lip and Palate Research
- Type
- article
- Field-Weighted Citation Impact
- 3.85
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province