Sustainable production of radionuclidically pure antimony-119
We report significant steps in overcoming barriers in <sup>119</sup>Sb production, chemical isolation and purification, enriched target material recycling, and chelation, helping promote accessibility and application of this promising therapeutic radionuclide. We describe a method for <sup>119</sup>Sb activity measurement using its low energy gamma (23.87 keV), negating the need for attenuation correction. Finally, we report the largest yet-measured <sup>119</sup>Sb production yields using proton and deuteron irradiation of natural and enriched targets and radioisotopic purity > 99.8% at end of purification.
Authors
- Paul A. Ellison (ORCID: https://orcid.org/0000-0002-8379-7419)
- Eduardo Aluicio‐Sarduy (ORCID: https://orcid.org/0000-0002-7889-9162)
- Jason C. Mixdorf (ORCID: https://orcid.org/0000-0003-3045-5607)
- Aeli P. Olson (ORCID: https://orcid.org/0000-0002-5511-6161)
- Jonathan W. Engle (ORCID: https://orcid.org/0000-0002-3399-7228)
- Robert J. Nickles
- Todd E. Barnhart
- Francesca Verich
Institutions
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s41181-024-00303-w
- Citations
- 5
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- U.S. Department of Energy
- National Institutes of Health
- Office of Science
- National Cancer Institute
- Office of Isotope R and D and Production