Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Voriconazole for Predicting the Clinical Outcomes of Adult Patients With Invasive Aspergillosis
Individual EC50 estimation can provide insights into in vivo host and organism responses. Elevated EC50 showed comparable and unfavorable trends to higher minimum inhibitory concentration. Thus, determining EC50 might help guide individualized target serum voriconazole levels.
Authors
- Wichai Santimaleeworagun (ORCID: https://orcid.org/0000-0001-9974-957X)
- Vasin Vasikasin (ORCID: https://orcid.org/0000-0002-1761-0978)
- Richard Wilson (ORCID: https://orcid.org/0000-0002-3275-6932)
- Worapong Nasomsong (ORCID: https://orcid.org/0000-0002-3486-8591)
- Alison Holmes (ORCID: https://orcid.org/0000-0001-5554-5743)
- Timothy M. Rawson (ORCID: https://orcid.org/0000-0002-2630-9722)
- Monchai Duangpraphat
Institutions
- University of Liverpool (GB)
- Hammersmith Hospital (GB)
- Phramongkutklao Hospital (TH)
- Imperial College London (GB)
- Silpakorn University (TH)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1097/ftd.0000000000001268
- Citations
- 1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.39