N-Alkyl Isofagomine Lactams: Synthesis, Glycosidase Inhibition, and Antimicrobial Assessments
Abstract A series of six N-alkyl isofagomine lactam derivatives is synthesized over ten steps from d-arabinose. The compounds are evaluated as glycosidase inhibitors. It was found that the N-alkyl groups have a detrimental effect on the glycosidase inhibition activities, as the prepared N-alkyl isofagomine lactam derivatives are much less potent glycosidase inhibitors than native isofagomine lactam.
Authors
- Óscar López (ORCID: https://orcid.org/0000-0003-2896-6993)
- Karl Kochanowski (ORCID: https://orcid.org/0000-0002-1884-7694)
- Magne O. Sydnes (ORCID: https://orcid.org/0000-0001-9413-6969)
- Monika Moreń
- Emil Lindbäck (ORCID: https://orcid.org/0000-0001-5809-7368)
- Marta Cerdà‐Cuéllar (ORCID: https://orcid.org/0000-0001-6842-1299)
- Ana Laura Pereira Lourenço (ORCID: https://orcid.org/0000-0002-7252-3105)
- Kåre B. Jørgensen
Institutions
- Universitat Autònoma de Barcelona (ES)
- Centre de Recerca en Sanitat Animal (ES)
- University of Bergen (NO)
- Universidad de Sevilla (ES)
- University of Stavanger (NO)
Publication Details
- Journal
- Synthesis
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1055/s-0043-1773494
- Citations
- 1
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Universitetet i Stavanger
- Ministerio de Ciencia e Innovación
- HORIZON EUROPE Framework Programme