Design of a compact beam transport system for laser-driven proton therapy

Abstract We put forward a new design of a compact beam transport system for intense laser-driven proton therapy, where instead of using conventional pulsed solenoids, our design relies on a helical coil irradiated by a nanosecond laser pulse to generate strong magnetic fields for focusing protons. A pair of dipole magnets and apertures are employed to further filter protons with large divergences and low energies. Our numerical studies combine particle-in-cell simulations for laser-plasma interaction to generate high-energy monoenergetic proton beams, finite element analysis for evaluating the magnetic field distribution inside the coil, and Monte-Carlo simulations for beam transport and energy deposition. Our results show that with this design, a spread-out Bragg peak in a range of several centimeters to a deep-seated tumor with a dose of approximately 16.5 cGy and fluctuation around 2% can be achieved. The instantaneous dose rate reaches up to 10 9 Gy/s, holding the potential for future FLASH radiotherapy research.

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Publication Details

Journal
Plasma Science and Technology
Published
2024-10-22
DOI
https://doi.org/10.1088/2058-6272/ad8a37
Primary Topic
Radiation Therapy and Dosimetry
Type
article
Field-Weighted Citation Impact
0.00

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article

Design of a compact beam transport system for laser-driven proton therapy

X. F. Shen, Yangfan Li, Bin Qiao, Yilin Yao
Plasma Science and Technology
Radiation Therapy and Dosimetry
article

Design of a compact beam transport system for laser-driven proton therapy

X. F. Shen, Yangfan Li, Bin Qiao, Yilin Yao
article en

Abstract

Abstract We put forward a new design of a compact beam transport system for intense laser-driven proton therapy, where instead of using conventional pulsed solenoids, our design relies on a helical coil irradiated by a nanosecond laser pulse to generate strong magnetic fields for focusing protons. A pair of dipole magnets and apertures are employed to further filter protons with large divergences and low energies. Our numerical studies combine particle-in-cell simulations for laser-plasma interaction to generate high-energy monoenergetic proton beams, finite element analysis for evaluating the magnetic field distribution inside the coil, and Monte-Carlo simulations for beam transport and energy deposition. Our results show that with this design, a spread-out Bragg peak in a range of several centimeters to a deep-seated tumor with a dose of approximately 16.5 cGy and fluctuation around 2% can be achieved. The instantaneous dose rate reaches up to 10 9 Gy/s, holding the potential for future FLASH radiotherapy research.

Plasma Science and TechnologyVol. 27(1)
Shanghai Jiao Tong University (CN), Peking University (CN), China Academy of Engineering Physics (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Affordable and clean energy
Openalex Percentile: Top 66%
Radiation Therapy and Dosimetry
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Design of a compact beam transport system for laser-driven proton therapy — X. F. Shen, Yangfan Li, et al. · Plasma Science and Technology (2024) | TGRS Research Map | TGRS