Role and mechanism of Actein on condylar bone metabolism in APOE deletion-induced osteoporotic mice
APOE<sup>-/-</sup> and ovariectomy induced OP, leading to OA-like lesions in condylar of mice. Actein promoted cartilage repair and trabecular bone recovery by increasing extracellular matrix synthesis (Col II, Col III, aggrecan), reversing the OA process, possibly through the Wnt/β-catenin/RUNX2 signaling pathway.
Authors
- Kaiao Zou (ORCID: https://orcid.org/0009-0006-5047-6922)
- Shuhui Tang
- Hongting Jin
- Haipeng Huang (ORCID: https://orcid.org/0000-0001-5375-7558)
- Jinjin Ma
- Qinghe Zeng (ORCID: https://orcid.org/0000-0001-7543-0329)
- Jianying Feng (ORCID: https://orcid.org/0000-0002-1048-7524)
- Yuqian Li (ORCID: https://orcid.org/0000-0003-1276-0077)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-0749-7836)
- Linyi Zhou
Institutions
- Qingdao University (CN)
- Zhejiang Chinese Medical University (CN)
- Qingdao Municipal Hospital (CN)
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Bone
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1016/j.bone.2024.117304
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Zhejiang Chinese Medical University
- Natural Science Foundation of Zhejiang Province