Direct Synthesis of 3,4‐Disubstituted Quinolines and 2‐Acylquinolines from Amines and Epoxides
Abstract Herein, we present a protocol starting from styrene oxide reacting with o ‐acylaniline and o ‐alkenylaniline derivatives to obtain 3,4‐disubstituted quinoline and 2‐acylquinoline derivatives, respectively, in 32–92% yields under specific conditions. Preliminary research outcomes underscore the versatility of our approach, as exemplified by its scalability for large‐scale synthesis, downstream derivatization, and the characteristic properties manifested by the modified molecules.
Authors
- Bingchuan Yang (ORCID: https://orcid.org/0000-0003-1195-5833)
- Shuai Fang (ORCID: https://orcid.org/0000-0003-4262-1545)
- Shichen Li (ORCID: https://orcid.org/0000-0002-2993-2544)
- Chen Ma (ORCID: https://orcid.org/0000-0001-8908-4658)
- Xiaotian Wu (ORCID: https://orcid.org/0009-0002-4770-0242)
- Xueyan Lv
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Shandong University (CN)
- Education University of Hong Kong (HK)
- Qilu Normal University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1002/adsc.202401055
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50