Unmasking the Origin of Cutaneous Metastasis: A Case Report

Cutaneous metastasis typically represents a late manifestation of internal malignancy. We present the case of a 60-year-old woman with a history of cervical cancer who presented with lower abdominal pain. Imaging studies revealed a high-grade carcinoma involving the urothelium, suggestive of primary urothelial carcinoma. Further investigation uncovered widespread metastatic disease, including cutaneous metastases to the arm and pelvis. Despite a comprehensive diagnostic workup, including immunohistochemical analysis, the primary tumor site could not be definitively identified, underscoring the challenges in diagnosing cutaneous metastases of unknown origin. This case highlights the necessity of considering metastatic disease in patients with atypical skin findings. Moreover, it emphasizes the aggressive nature of cutaneous metastases, particularly those originating from urothelial carcinomas, which are associated with a poor prognosis and limited treatment options.

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Publication Details

Journal
Cureus
Published
2024-10-22
DOI
https://doi.org/10.7759/cureus.72156
Primary Topic
Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Unmasking the Origin of Cutaneous Metastasis: A Case Report

Angélica Rivera, Alice Kesler, Zein Barakat, Paola Campillo et al.
Cureus
Cancer Diagnosis and Treatment
article

Unmasking the Origin of Cutaneous Metastasis: A Case Report

Angélica Rivera, Alice Kesler, Zein Barakat, Paola Campillo, Ganga B Ramidi
article en

Abstract

Cutaneous metastasis typically represents a late manifestation of internal malignancy. We present the case of a 60-year-old woman with a history of cervical cancer who presented with lower abdominal pain. Imaging studies revealed a high-grade carcinoma involving the urothelium, suggestive of primary urothelial carcinoma. Further investigation uncovered widespread metastatic disease, including cutaneous metastases to the arm and pelvis. Despite a comprehensive diagnostic workup, including immunohistochemical analysis, the primary tumor site could not be definitively identified, underscoring the challenges in diagnosing cutaneous metastases of unknown origin. This case highlights the necessity of considering metastatic disease in patients with atypical skin findings. Moreover, it emphasizes the aggressive nature of cutaneous metastases, particularly those originating from urothelial carcinomas, which are associated with a poor prognosis and limited treatment options.

CureusVol. 16(10)
Lakeland Regional Medical Center (US)
Openalex Percentile: Top 67%
Cancer Diagnosis and Treatment
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Unmasking the Origin of Cutaneous Metastasis: A Case Report — Angélica Rivera, Alice Kesler, et al. · Cureus (2024) | TGRS Research Map | TGRS