Slow dissociation kinetics of fentanyls and nitazenes correlates with reduced sensitivity to naloxone reversal at the μ‐opioid receptor
With fentanyls and nitazenes that slowly dissociate from the μ receptor, antagonism by naloxone is pseudo-competitive. In overdoses involving fentanyls and nitazenes, higher doses of naloxone may be required for reversal than those normally used to reverse heroin overdose.
Authors
- Norah Alhosan (ORCID: https://orcid.org/0000-0002-7545-0263)
- Graeme Henderson (ORCID: https://orcid.org/0000-0001-6050-0048)
- Marina Santiago (ORCID: https://orcid.org/0000-0001-9388-8309)
- Damiana Cavallo (ORCID: https://orcid.org/0000-0003-3985-8568)
- Eamonn Kelly
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- University of Bristol (GB)
- Macquarie University (AU)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1111/bph.17376
- Citations
- 10
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- Princess Nourah Bint Abdulrahman University
- Medical Research Council