Intravitreal indocyanine green is toxic to the retinal cells
The exposure of ICG or its solvent leads to an augmented retinal cell death, which is directly proportional to the concentration and duration of exposure, both in vivo and in vitro. Caution should be exercised during vitrectomy procedures involving ICG administration during clinical practice. It is recommended to advocate for lower concentrations of ICG with reduced exposure time during ocular surgeries.
Authors
- Dawei Luo (ORCID: https://orcid.org/0000-0001-7948-4164)
- Jingfa Zhang (ORCID: https://orcid.org/0000-0003-0601-4342)
- Hai Xie (ORCID: https://orcid.org/0000-0001-5950-6573)
- Chaoyang Zhang (ORCID: https://orcid.org/0000-0002-9450-1812)
- Jingting Zhang (ORCID: https://orcid.org/0000-0003-3378-2363)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Shanghai First People's Hospital (CN)
- He Eye Hospital (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1016/j.bbrc.2024.150872
- Citations
- 4
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- Shanghai Professional Technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation
- Natural Science Foundation for Young Scientists of Shanxi Province