Electrochemical Cyclopropanation of 1,3-Dialkyl Bromides
An electrochemical synthesis of mono- and 1,1-disubstituted cyclopropanes is demonstrated. Starting from readily available 1,3-dialkyl bromides, this method hinges on the integration of a sacrificial reductant alongside cost-effective cathode and anode materials. The refined approach eliminates the necessity for a divided cell and the use of hazardous or costly electrodes, thereby streamlining the transition of this protocol to a continuous flow system. In addition, an alternative protocol that utilizes a simple sacrificial anode is also described.
Authors
- Sylvain Charvet (ORCID: https://orcid.org/0000-0003-1612-9338)
- Pierre‐Georges Echeverria (ORCID: https://orcid.org/0000-0001-9938-5083)
- Julien C. Vantourout (ORCID: https://orcid.org/0000-0002-0602-069X)
- Clément Jacob (ORCID: https://orcid.org/0009-0004-8691-6788)
- Guillaume Tintori
- Aurore Dietsch
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (FR)
- École d'Ingénieurs en Chimie et Sciences du Numérique (FR)
- Syngenta (Switzerland) (CH)
Publication Details
- Journal
- Organic Process Research & Development
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1021/acs.oprd.4c00302
- Citations
- 3
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Centre National de la Recherche Scientifique
- Université Claude Bernard Lyon 1
- Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation