Treatment regimens for laryngeal and hypopharyngeal squamous cell carcinoma: a “real life” multicenter study of 2307 patients
Comparable survival rates were demonstrated for cT1/2N0M0 laryngeal and hypopharyngeal SCC compared with primary chemo-/radiotherapy and larynx-preserving surgery. Better OS was achieved after surgery in nodal-positive patients and in those with locally advanced disease. Tumor recurrence should be anticipated in up to 39% of cases. Glottic cancer recurrence can be successfully and safely treated with L(P)E, whereas OS is reduced in hypopharyngeal cancer and possibly in supraglottic cancer.
Authors
- Manuel Christoph Ketterer (ORCID: https://orcid.org/0000-0003-0391-6607)
- Andreas Knopf
- Roland Laszig
- Jens Peter Klußmann (ORCID: https://orcid.org/0000-0002-8223-7954)
- Simon Laban (ORCID: https://orcid.org/0000-0001-6732-7137)
- Christian Jacobi (ORCID: https://orcid.org/0000-0002-3112-8459)
- H. Bier (ORCID: https://orcid.org/0000-0002-0346-3612)
- Thomas K. Hoffmann (ORCID: https://orcid.org/0000-0001-5127-3779)
- Martin Canis
- Alexander Berghaus
- Jens Pfeiffer
- Wendelin Föringer
Institutions
- University of Freiburg (DE)
- University of Cologne (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Medical Center Freiburg (DE)
- TUM Klinikum (DE)
- Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde (DE)
- Hals- Nasen- und Ohrenklinik Gießen (DE)
- Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde (DE)
- Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde (DE)
Publication Details
- Journal
- European Archives of Oto-Rhino-Laryngology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1007/s00405-024-08990-6
- Citations
- 4
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- Technische Universität München