An endogenous cholinergic system controls electrical conduction in the heart
This study identifies an integrated cholinergic system inherent to the heart, rather than external nerves that can effectively control cardiac electrical conduction. The discovery reveals arrhythmia mechanisms beyond classical theories and opens new directions for arrhythmia research.
Authors
- Duanyang Xie (ORCID: https://orcid.org/0000-0002-2651-2202)
- Qicheng Zou
- Luxin Wang (ORCID: https://orcid.org/0000-0003-4959-6477)
- Xuling Su
- Beihua Shao
- Yu Kong (ORCID: https://orcid.org/0000-0001-6271-4082)
- Bin Zhou (ORCID: https://orcid.org/0000-0001-9000-5320)
- Nianguo Dong (ORCID: https://orcid.org/0000-0001-5437-599X)
- Jian Yang (ORCID: https://orcid.org/0000-0002-1964-7061)
- Yi Liu (ORCID: https://orcid.org/0000-0001-9701-6460)
- Zhiwen Chen (ORCID: https://orcid.org/0000-0002-4759-0904)
- Ke Xiong
- Wenli Bai
- Yihan Chen (ORCID: https://orcid.org/0000-0003-1000-1835)
- Guanghua Wang
- Xu Wang (ORCID: https://orcid.org/0009-0004-6052-9130)
Institutions
- Tongji University (CN)
- Academy of Medical Sciences (GB)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Center for Excellence in Molecular Cell Science (CN)
- Shanghai East Hospital (CN)
- State Key Laboratory of Cardiovascular Disease
- Huazhong University of Science and Technology (CN)
- Academia Sinica (TW)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1093/eurheartj/ehae699
- Citations
- 21
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 4.91
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Nanjing Medical University
- Collaborative Innovation Center for Cardiovascular Disease Translational Medicine
- Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
- Shanghai Key Discipline Construction Project
- Fundamental Research Funds for the Central Universities
- National Research, Development and Innovation Office