Inoculum effect of cefiderocol against NDM-1 producing <i>Escherichia coli in vitro</i> and in a murine model of peritonitis
A significant inoculum effect of cefiderocol was observed in vitro for 62-pTOPO and 62-pTOPO-NDM. However, the effectiveness of cefiderocol was not reduced in vivo with a high bacterial inoculum. In vitro inoculum effect of cefiderocol may not be clinically significant.
Authors
- A. Lefort (ORCID: https://orcid.org/0000-0002-4507-6426)
- Victoire de Lastours (ORCID: https://orcid.org/0000-0003-1160-2069)
- Ariane Amoura (ORCID: https://orcid.org/0000-0002-9986-4700)
- Agnès B. Jousset (ORCID: https://orcid.org/0000-0002-8223-2213)
- Vincent Jullien (ORCID: https://orcid.org/0000-0002-5971-6316)
- Sophie Magréault (ORCID: https://orcid.org/0000-0003-4786-3965)
- André Birgy (ORCID: https://orcid.org/0000-0001-9462-0582)
- Imane El Meouche (ORCID: https://orcid.org/0000-0002-0886-6752)
- Bruno Fantin
- Claire Pistien
- Anne-Sophie Godron
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Hôpital Beaujon (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Robert-Debré (FR)
- Hôpital Avicenne (FR)
- Bicêtre Hospital (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1093/jac/dkae368
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale