Fraxinellone protects against cardiac injury and decreases ventricular fibrillation susceptibility during myocardial ischemia-reperfusion
FRA may exert cardioprotective effects during MIRI by inhibiting myocardial inflammation, oxidative stress and apoptosis, and decrease VF susceptibility by improving sympathetic remodeling and ion channel remodeling, which might represent a potential therapeutic strategy for attenuation of MIRI.
Authors
- Yuhua Lei (ORCID: https://orcid.org/0000-0002-7149-1439)
- Pingzhang Tang (ORCID: https://orcid.org/0009-0009-8612-3928)
- Dan Luo (ORCID: https://orcid.org/0000-0002-8202-7420)
- Qingning Huang
- Rui Huang (ORCID: https://orcid.org/0000-0001-5561-8746)
- Ye Lu
- Xing Zhong (ORCID: https://orcid.org/0009-0008-8374-4801)
- Xin Chen (ORCID: https://orcid.org/0000-0003-2180-5564)
- Yaqin Yang
Institutions
- The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1016/j.biopha.2024.117560
- Citations
- 2
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.50