DIONYSUS: a database of protein–carbohydrate interfaces
Protein-carbohydrate interactions govern a wide variety of biological processes and play an essential role in the development of different diseases. Here, we present DIONYSUS, the first database of protein-carbohydrate interfaces annotated according to structural, chemical and functional properties of both proteins and carbohydrates. We provide exhaustive information on the nature of interactions, binding site composition, biological function and specific additional information retrieved from existing databases. The user can easily search the database using protein sequence and structure information or by carbohydrate binding site properties. Moreover, for a given interaction site, the user can perform its comparison with a representative subset of non-covalent protein-carbohydrate interactions to retrieve information on its potential function or specificity. Therefore, DIONYSUS is a source of valuable information both for a deeper understanding of general protein-carbohydrate interaction patterns, for annotation of the previously unannotated proteins and for such applications as carbohydrate-based drug design. DIONYSUS is freely available at www.dsimb.inserm.fr/DIONYSUS/.
Authors
- Frédéric Guyon (ORCID: https://orcid.org/0000-0003-3740-1839)
- Aria Gheeraert (ORCID: https://orcid.org/0000-0001-7493-8702)
- Ravy Leon Foun Lin
- Gabriel Cretin (ORCID: https://orcid.org/0000-0002-3522-7083)
- Jean‐Christophe Gelly (ORCID: https://orcid.org/0000-0001-5138-361X)
- Yann Vander Meersche (ORCID: https://orcid.org/0000-0002-6680-8104)
- Tatiana Galochkina (ORCID: https://orcid.org/0000-0002-3608-5208)
- Yani Ren (ORCID: https://orcid.org/0009-0009-3426-2897)
- Ali Hamraoui
- Serge Pérez
- Thomas Bailly
- Julie Te
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Centre de Recherches sur les Macromolécules Végétales (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut de Biologie de l'École Normale Supérieure (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Nucleic Acids Research
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1093/nar/gkae890
- Citations
- 6
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Institut Français de Bioinformatique
- National Institute for Health and Care Research
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Grand Équipement National De Calcul Intensif