Oxysterols contribute to immune cell recruitment in SLE skin lesions
Our findings reveal a potential mechanism by which fibroblasts contribute to immune cell recruitment in SLE skin lesions by expression of CH25H and CYP7B1. This study underscores the significance of oxysterol metabolism in SLE skin lesion pathogenesis and highlights potential therapeutic targets for SLE skin lesion treatment.
Authors
- Lianlian Ouyang
- Ming Zhao (ORCID: https://orcid.org/0000-0002-1320-1093)
- Sujie Jia (ORCID: https://orcid.org/0000-0002-8227-5280)
- Xiaoyun Chen (ORCID: https://orcid.org/0009-0004-6778-9787)
Institutions
- Central South University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s13075-024-03414-6
- Citations
- 4
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences