Anticipation in families with <i>MLH1</i>‐associated Lynch syndrome
The current results demonstrated evidence in support of anticipation in families with MLH1-associated LS across all statistical models. Mutational effects on Mlh1 activity influenced the hazard for CRC/EC. Screening based on the youngest age of cancer diagnosis in MLH1-LS families is recommended.
Authors
- Dezheng Huo (ORCID: https://orcid.org/0000-0002-4041-1678)
- Shreshtha Garg
- Christine M. Drogan (ORCID: https://orcid.org/0000-0002-9927-9739)
- Sonia S. Kupfer (ORCID: https://orcid.org/0000-0003-4857-2289)
- Kristen J. Vogel Postula
- Arti Pandey (ORCID: https://orcid.org/0000-0002-0262-5835)
Institutions
- Northwestern University (US)
- St. Jude Children's Research Hospital (US)
- Chicago Department of Public Health (US)
- University of Chicago (US)
- Helix (United States) (US)
Publication Details
- Journal
- Cancer
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1002/cncr.35589
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.42