Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system
Autophagy is a cellular degradation and recycling system, indispensable for cellular and organ development, homeostasis, and function. This cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles, which finally recycle components as amino acids. This process is effective during normal physiology as part of anabolism and plays an additional important role during starvation (Dikic and Elazar, 2018). Different types of autophagy have been characterized based on their dynamic, mechanism of action, target substrates, and protein markers. Some of them are macroautophagy (hereafter called “autophagy”), microautophagy, and chaperone-mediated autophagy (Fleming et al., 2022).
Authors
- Mario Villa (ORCID: https://orcid.org/0000-0003-4631-2555)
- Lara Ordóñez‐Gutiérrez (ORCID: https://orcid.org/0000-0003-2778-7774)
- Irene Benito‐Cuesta (ORCID: https://orcid.org/0000-0002-2958-3188)
- Francisco Wandosell (ORCID: https://orcid.org/0000-0001-6537-2321)
- Marta García‐Juan (ORCID: https://orcid.org/0000-0001-8958-0504)
Institutions
- Universidad Complutense de Madrid (ES)
- Karolinska University Hospital (SE)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Centro de Biología Molecular Severo Ochoa (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Neural Regeneration Research
- Published
- 2024-10-22
- DOI
- https://doi.org/10.4103/nrr.nrr-d-24-00733
- Citations
- 5
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Banco Santander
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas