Metformin Exhibits Anti‐Inflammatory Effects by Regulating <scp>microRNA</scp>‐451/<scp>CXCL16</scp> and B Cell Leukemia/Lymphoma 2 in Patients With Osteoarthritis
The effects of metformin in reducing pain can be attributed to many factors, including its anti-inflammatory and antiaging effects. Our findings suggest that metformin may reduce pain and inflammation in patients with OA through the regulation of miR-451/CXCL16 and BCL-2.
Authors
- Nahid Alimoradi (ORCID: https://orcid.org/0000-0002-1992-0312)
- Mohammad Tahami (ORCID: https://orcid.org/0000-0002-3722-8426)
- Amin Ramezani (ORCID: https://orcid.org/0000-0001-5655-8722)
- Negar Firouzabadi (ORCID: https://orcid.org/0000-0002-9293-9845)
Institutions
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1002/acr2.11755
- Citations
- 6
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.82
Funders
- Shiraz University of Medical Sciences