Cytokine production in an ex vivo model of SARS-CoV-2 lung infection
Our results generally reflect the data obtained in COVID-19 patients. GRO-a, IFN-g, IL-6, IL-8, MCP-1, MCP-3, and RANTES correlated with the viral load, forming a distinct pro-inflammatory cluster. Thus, our lung <i>ex vivo</i> model faithfully reproduces some aspects of cytokine alterations in COVID-19 patients at an early disease stage, making the investigation of SARS-CoV-2 infection mechanisms more accessible and providing a potential platform for antiviral drug testing.
Authors
- Elena Vasilieva (ORCID: https://orcid.org/0000-0003-4111-0874)
- Gintsburg Al (ORCID: https://orcid.org/0000-0003-1769-5059)
- Denis Y. Logunov (ORCID: https://orcid.org/0000-0003-4035-6581)
- Natalia Pinegina
- Anna V. Kovyrshina (ORCID: https://orcid.org/0000-0002-8757-7026)
- Anna Kalinskaya (ORCID: https://orcid.org/0000-0003-2316-4238)
- Fedor N. Rozov (ORCID: https://orcid.org/0000-0002-8628-2883)
- Anna V. Tvorogova (ORCID: https://orcid.org/0000-0002-8205-1914)
- George Rusakovich (ORCID: https://orcid.org/0000-0001-7577-704X)
- Leonid Margolis (ORCID: https://orcid.org/0000-0002-1960-1928)
- Daria M. Potashnikova (ORCID: https://orcid.org/0000-0002-0098-827X)
- Inna V. Dolzhikova (ORCID: https://orcid.org/0000-0003-2548-6142)
- D. Yu. Kanner (ORCID: https://orcid.org/0000-0002-0649-6452)
- Elena Maryukhnich (ORCID: https://orcid.org/0000-0001-9833-1227)
- Tatiana N Sotnikova
- Daria Vorobyeva
- Alexander B. Postnikov
Institutions
- Ilia State University (GE)
- Ministry of Health of the Russian Federation (RU)
- HyTest (Finland) (FI)
- City Clinical Hospital (RU)
- Moscow City Oncology Hospital №62 (RU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-21
- DOI
- https://doi.org/10.3389/fimmu.2024.1448515
- Citations
- 1
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.39