<i>Gpr55</i> deficiency crucially alters cardiomyocyte homeostasis and counteracts angiotensin II induced maladaption in female mice
Our study suggests GPR55 as crucial regulator of cardiomyocyte hypertrophy and homeostasis presumably by regulating PKC/PKA-PLM and PKG signalling, and identifies the receptor as potential target to counteract maladaptation, adrenergic desensitization and metabolic shifts as unfavourable features of the hypertrophied heart in females.
Authors
- Alexander Nickel (ORCID: https://orcid.org/0000-0002-2562-0439)
- Sarah‐Lena Puhl (ORCID: https://orcid.org/0000-0002-0556-5874)
- Emiel P. C. van der Vorst (ORCID: https://orcid.org/0000-0001-5771-6278)
- Michael Kohlhaas (ORCID: https://orcid.org/0000-0001-6132-6037)
- Christoph Maack (ORCID: https://orcid.org/0000-0003-3694-4559)
- Sabine Steffens (ORCID: https://orcid.org/0000-0002-6892-9751)
- Anna‐Florentine Schiuma
- Sanne L. Maas (ORCID: https://orcid.org/0000-0003-1423-8901)
- Yi Xuan Shia
- B. Schopohl
Institutions
- Maastricht University Medical Centre (NL)
- Universitätsklinikum Würzburg (DE)
- German Centre for Cardiovascular Research (DE)
- Ludwig-Maximilians-Universität München (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1111/bph.17350
- Citations
- 4
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- Barth Syndrome Foundation
- Deutsche Forschungsgemeinschaft
- Fritz Thyssen Stiftung
- Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.