TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model
These findings suggest that chronic TLR4 stimulation in tau-transgenic mice results in significant microglial activation but does not influence tau tangle formation. This underscores the complexity of the relationship between neuroinflammation and tau pathology, indicating that additional mechanisms may be required for neuroinflammation to directly contribute to tau tangle formation.
Authors
- Stanislav Katina (ORCID: https://orcid.org/0000-0002-3256-5482)
- Muhammad Khalid Muhammadi
- Neha Basheer (ORCID: https://orcid.org/0000-0003-3669-3825)
- Norbert Žilka (ORCID: https://orcid.org/0000-0003-2397-2083)
- Tomáš Smolek (ORCID: https://orcid.org/0000-0002-1959-0069)
- Carlos L. Freites (ORCID: https://orcid.org/0000-0002-5254-8145)
- Martin Avila (ORCID: https://orcid.org/0000-0002-8666-2595)
- Miraj Ud Din Momand
- N. B. Hryntsova
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional de Cuyo (AR)
- Slovak Academy of Sciences (SK)
- Masaryk University (CZ)
- Czech Academy of Sciences, Institute of Mathematics (CZ)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- Instituto de Histología y Embriología de Mendoza (AR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-10-21
- DOI
- https://doi.org/10.3389/fnagi.2024.1468602
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25