Pancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains
Clonal β-cells and ND human islets produce abundant EVs. In cell culture, appreciable DOC2B can be packaged into EVs, and a small fraction is excreted as a soluble protein. While DOC2B-laden EVs and soluble protein are present in ND plasma, further studies will be necessary to determine if DOC2B originating from β-cells significantly contributes to the plasma secretome.
Authors
- Fouad Kandeel (ORCID: https://orcid.org/0000-0003-3746-5015)
- Eunjin Oh (ORCID: https://orcid.org/0009-0003-9437-0570)
- Nan Jiang (ORCID: https://orcid.org/0000-0001-8460-3949)
- Diana Esparza
- Sarah Abuelreich (ORCID: https://orcid.org/0000-0002-0476-5946)
- Ayelet Lenz (ORCID: https://orcid.org/0000-0001-7204-7201)
- Debbie C. Thurmond (ORCID: https://orcid.org/0000-0002-6303-4596)
- Tijana Jovanović‐Talisman (ORCID: https://orcid.org/0000-0003-1928-4763)
- Ima Ghaeli
- Jinhee Hwang (ORCID: https://orcid.org/0000-0001-5637-2768)
- Carinna Lima (ORCID: https://orcid.org/0000-0003-4240-0400)
- Angel Gu
Institutions
- City of Hope (US)
- Beckman Research Institute
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-10-21
- DOI
- https://doi.org/10.3389/fendo.2024.1451279
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Ford Foundation
- Larry L. Hillblom Foundation
- National Institutes of Health
- National Cancer Institute