Harnessing Magnetic Resonance-Guided Focused Ultrasound for Precise Blood-Brain Barrier Disruption: Advancements in Targeted Therapeutics for Neurological Disorders

This review examines the latest advancements in the clinical application of Magnetic Resonance-guided Focused Ultrasound (MRgFUS), also referred to as Magnetic Resonance High-Intensity Focused Ultrasound (MR-HIFUS), for transiently permeabilizing the blood-brain barrier (BBB), thereby enhancing drug delivery for neurological disorders treatments. Extensive preclinical studies and human safety trials have established a robust safety profile for MRgFUS, supporting its use in conditions such as Alzheimer's disease, Parkinson's disease, and brain tumors. By disrupting the BBB, MRgFUS facilitates the targeted delivery of systemic medications to specific brain regions, significantly improving therapeutic efficacy.