Rebound effect of hypothalamic-pituitary thyreotropic activity: a new model to better understand hypothyroidism
The study highlights new mechanisms that influence HPta. HPta progressively reduces with age, and this must be considered when evaluating TSH values in the elderly. Furthermore, we report for the first time a rebound effect of HPta, determined by the dose pro Kg/die of LT4 taken prior to its discontinuation. Inflammation and metabolic status also affect these phenomena.
Authors
- Tommaso Piticchio (ORCID: https://orcid.org/0000-0002-0567-6494)
- Pierpaolo Trimboli (ORCID: https://orcid.org/0000-0002-2125-4937)
- D. Salvatore
- Francesco Frasca (ORCID: https://orcid.org/0000-0002-5556-3201)
- Cristina Luongo (ORCID: https://orcid.org/0000-0002-9127-4538)
Institutions
- Università degli Studi di Enna Kore (IT)
- University of Catania (IT)
- Ente Ospedaliero Cantonale (CH)
- Ospedale Garibaldi (IT)
- Università della Svizzera italiana (CH)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Endocrinological Investigation
- Published
- 2024-10-21
- DOI
- https://doi.org/10.1007/s40618-024-02480-6
- Citations
- 5
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.79