Activating STAT3 mutations in CD8+ T-cells correlate to serological positivity in rheumatoid arthritis
<i>STAT3</i> activating mutations were detected in RA patient CD8+ cells and associated with seropositivity. Thus, <i>STAT3</i> activating mutations may play a role in disease pathogenesis in a subset of RA patients.
Authors
- William D. Baker (ORCID: https://orcid.org/0000-0002-5194-5739)
- Aakrosh Ratan (ORCID: https://orcid.org/0000-0002-0782-3056)
- Cait E. Hamele (ORCID: https://orcid.org/0000-0003-0077-7840)
- Donald L. Kimpel
- Jesse Boodoo
- Gitanjali Khurana
- Thomas L. Olson (ORCID: https://orcid.org/0000-0001-7906-205X)
- Felipe Andrade (ORCID: https://orcid.org/0000-0003-3415-0704)
- M. Schmachtenberg
- Marieke Jones (ORCID: https://orcid.org/0000-0001-5045-6725)
- Bryna C. Shemo (ORCID: https://orcid.org/0000-0003-0029-3336)
- Thomas P. Loughran (ORCID: https://orcid.org/0000-0003-4363-8947)
- Erika Darrah (ORCID: https://orcid.org/0000-0003-1119-0279)
- Katharine B. Moosic (ORCID: https://orcid.org/0000-0001-6736-4392)
- Kristine C. Olson (ORCID: https://orcid.org/0000-0002-2952-3003)
- Samara Khalique
- David J. Feith (ORCID: https://orcid.org/0000-0003-4981-1691)
- Mark Freijat
- Trevor Duffy
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Virginia Cancer Center
- University of Virginia (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-21
- DOI
- https://doi.org/10.3389/fimmu.2024.1466276
- Citations
- 2
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- National Institutes of Health
- National Cancer Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases