Scutellarein ameliorates dextran sulfate sodium-induced ulcerative colitis by inhibiting colonic epithelial cell proinflammation and barrier disruption
These data demonstrate that Scu is an efficacious therapeutic agent to treat UC. Inhibition of inflammatory responses and maintenance of epithelial barrier integrity through NF-κB signaling pathway underlines Scu therapeutic effect on UC.
Authors
- Yujing Wang (ORCID: https://orcid.org/0000-0003-2197-8983)
- Zhengyu Cao (ORCID: https://orcid.org/0000-0002-2692-2949)
- Qin Xu (ORCID: https://orcid.org/0000-0003-1812-3108)
- Wenjie Huang (ORCID: https://orcid.org/0000-0002-0064-1823)
- Qinglian Tang (ORCID: https://orcid.org/0000-0003-0118-0739)
- Zhengyuan Lu (ORCID: https://orcid.org/0000-0003-1216-8778)
- Haidong Jia (ORCID: https://orcid.org/0009-0002-4875-1893)
Institutions
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-21
- DOI
- https://doi.org/10.3389/fphar.2024.1479441
- Citations
- 4
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 1.79