Fecal bile acid dysmetabolism and reduced ursodeoxycholic acid correlate with novel microbial signatures in feline chronic kidney disease
The gut-kidney axis mediated through microbial-derived SBAs appears relevant to the spontaneous animal CKD model of domestic cats. This includes reduced fecal concentrations of the microbial-derived SBA UDCA, known to regulate inflammation and fibrosis and be reno-protective. Microbes correlated with fecal SBAs include <i>bai</i> operon containing <i>P. hiranonis</i>, as well as members of <i>Oscillospirales</i>, which also harbor a functional <i>bai</i> operon. Ultimately, CKD cats represent a translational opportunity to study the role of SBAs in the gut-kidney axis, including the potential to identify novel microbial-directed therapeutics to mitigate CKD pathogenesis in veterinary patients and humans alike.
Authors
- John C. Rowe (ORCID: https://orcid.org/0000-0002-6662-2983)
- Jessica M. Quimby (ORCID: https://orcid.org/0000-0002-1388-0452)
- Stacie Summers (ORCID: https://orcid.org/0000-0002-1512-9603)
- Jenessa A. Winston (ORCID: https://orcid.org/0000-0001-5323-7683)
Institutions
- Oregon State University (US)
- The Ohio State University (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-10-21
- DOI
- https://doi.org/10.3389/fmicb.2024.1458090
- Citations
- 8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Institutes of Health
- Cancer Center, University of Colorado
- National Institute of Allergy and Infectious Diseases