The role of micronutrients and serum metabolites in intervertebral disk degeneration: insights from a Mendelian randomization study and mediation analysis
This study has shown that vitamin B12 may reduce the risk of IVDD and has identified 52 serum metabolites that are associated with IVDD. Furthermore, it proposes that 4-acetaminophen sulfate could serve as a potential mechanism by which vitamin B12 exerts its inhibitory effects on IVDD.
Authors
- Quanxiang Wang (ORCID: https://orcid.org/0000-0002-4711-2742)
- Lei Li (ORCID: https://orcid.org/0000-0001-9333-5667)
- Nizhou Jiang (ORCID: https://orcid.org/0000-0001-9099-5010)
- Jian Jiang (ORCID: https://orcid.org/0000-0002-3249-8857)
Institutions
- Dalian Medical University (CN)
- Dalian University of Technology (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2024-10-21
- DOI
- https://doi.org/10.3389/fnut.2024.1428403
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dalian University of Technology
- Natural Science Foundation of Liaoning Province