Whole‐genome sequencing study in Koreans identifies novel loci for Alzheimer's disease
Novel genome-wide significant associations for AD identified with ROCK2 and MICALL1. ROCK2 and MICALL1 are differentially expressed between AD cases and controls in the brain. This is the largest whole-genome-sequence study of AD in an East Asian population.
Authors
- Moon-Il Kang (ORCID: https://orcid.org/0000-0001-5932-6804)
- John Farrell (ORCID: https://orcid.org/0000-0002-8726-5997)
- Jungsoo Gim (ORCID: https://orcid.org/0000-0002-6454-9751)
- Hyeonseul Park
- Gyungah Jun (ORCID: https://orcid.org/0000-0002-3230-8697)
- Kyu Yeong Choi (ORCID: https://orcid.org/0000-0003-1872-6953)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Kun Ho Lee
- Eun Hyun Seo (ORCID: https://orcid.org/0000-0002-4764-7464)
- Sarang Kang (ORCID: https://orcid.org/0000-0001-7808-0985)
- Sungho Won (ORCID: https://orcid.org/0000-0001-5751-5089)
- Congcong Zhu (ORCID: https://orcid.org/0000-0002-1657-8726)
Institutions
- Boston University (US)
- Seoul National University (KR)
- Chosun University (KR)
- Korea Brain Research Institute (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1002/alz.14128
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- Illinois Department of Public Health
- Rush University
- Translational Genomics Research Institute
- Korea Brain Research Institute
- Ministry of Science and ICT, South Korea
- National Institute on Aging