Association of CSF α‐synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study
Seed amplification assay (SAA) positivity was associated with greater cognitive decline and earlier symptom onset. Thirty-four Alzheimer's Disease Neuroimaging Initiative (ADNI) individuals progressed from SAA- to SAA+, that is, ≈ 5% conversion. SAA conversion was associated with amyloid beta (Aβ) pathology and greater cognitive decline. SAA status did not impact the progression of either CSF Aβ42 or phosphorylated tau181 biomarkers. Change in clinical diagnosis was associated with both Alzheimer's disease biomarkers and SAA. SAA kinetic parameters were associated with clinical features and progression.
Authors
- Jennifer Lamoureux
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-8644-7724)
- Luis Concha‐Marambio (ORCID: https://orcid.org/0000-0002-9454-8389)
- Russ Lebovitz
- Pamela Thropp (ORCID: https://orcid.org/0009-0006-5371-8667)
- Zachary Hausle
- Leslie M. Shaw (ORCID: https://orcid.org/0000-0002-7650-1210)
- Michael Walter Weiner (ORCID: https://orcid.org/0000-0002-0144-1954)
- Andrew B. Singleton
Institutions
- National Institutes of Health (US)
- University of California, San Francisco (US)
- University of California System (US)
- National Institute of Neurological Disorders and Stroke (US)
- Amprion (United States) (US)
- National Institute on Aging (US)
- Northern California Institute for Research and Education (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1002/alz.14276
- Citations
- 23
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Institute on Aging