Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole‐genome sequencing from the Alzheimer's Disease Sequencing Project
We determine the association of genetic variants with Alzheimer's disease (AD) using 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data. We identified genetic variants at apolipoprotein E (APOE), BIN1, PSEN1, and LINC00320 associated with AD. We observed rare non-coding variants in the promoter of TOMM40 distinct of APOE.
Authors
- Wan‐Ping Lee (ORCID: https://orcid.org/0000-0002-5305-1181)
- Anita L. DeStefano (ORCID: https://orcid.org/0000-0002-9335-2819)
- Ellen M. Wijsman (ORCID: https://orcid.org/0000-0002-2725-6669)
- Elizabeth Blue (ORCID: https://orcid.org/0000-0002-0633-0305)
- Margaret G. Shea (ORCID: https://orcid.org/0000-0002-4045-4758)
- Achilleas Pitsillides (ORCID: https://orcid.org/0000-0002-2658-1566)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Eric Boerwinkle
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0001-8237-1857)
- Honghuang Lin (ORCID: https://orcid.org/0000-0003-3043-3942)
- Yuk Yee Leung (ORCID: https://orcid.org/0000-0002-3047-5440)
- Li‐San Wang (ORCID: https://orcid.org/0000-0002-3684-0031)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Amanda B Kuzma (ORCID: https://orcid.org/0000-0002-6064-5420)
- Seung Hoan Choi (ORCID: https://orcid.org/0000-0002-2797-3190)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Beth A. Dombroski (ORCID: https://orcid.org/0000-0002-5334-1306)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- Po‐Liang Cheng (ORCID: https://orcid.org/0009-0007-0046-0313)
- Nancy L. Heard‐Costa (ORCID: https://orcid.org/0000-0001-9730-0306)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- John J. Farrell (ORCID: https://orcid.org/0000-0001-6502-1572)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Brian W. Kunkle (ORCID: https://orcid.org/0000-0002-9515-5157)
- Katia Bulekova
- Frederick Nusetor
- Hui Wang (ORCID: https://orcid.org/0000-0002-3394-1531)
- Dongyu Wang (ORCID: https://orcid.org/0000-0002-1317-2739)
- Gina M. Peloso
- Josée Dupuis
- Myriam Fornage
- Margaret Pericak‐Vance
- Gerard D. Schellenberg
- Jonathan L. Haines
Institutions
- Boston University (US)
- University of Miami (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Massachusetts Chan Medical School (US)
- Baylor College of Medicine (US)
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- University of Washington Medical Center (US)
- University of Massachusetts Boston (US)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- Dr. John T. Macdonald Foundation (US)
- Brotman Baty Institute (US)
- Brown Foundation (US)
- Baylor Genetics (US)
- McGill University (CA)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1002/alz.14283
- Citations
- 19
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 9.91
Funders
- National Institute on Aging