Development and Validation of an Improved HPLC-MS/MS Method for Quantifying Total and Unbound Lenalidomide in Human Plasma
We developed a highly reproducible, sensitive, and efficient bioanalytical method using a smaller volume of plasma sample (50 μL) with a relatively short run time (2.5 min). The proposed analytical method was successfully applied to measure total and unbound lenalidomide concentrations at various time points in multiple myeloma patients with renal impairment.
Authors
- Suein Choi (ORCID: https://orcid.org/0000-0001-5438-7819)
- Donghyun Kim (ORCID: https://orcid.org/0000-0002-3429-7557)
- Eunseo Song (ORCID: https://orcid.org/0009-0000-5927-7168)
- Seungwon Yang (ORCID: https://orcid.org/0000-0002-0819-2954)
- Seunghoon Han (ORCID: https://orcid.org/0000-0002-9976-5120)
- Eun Kyoung Chung (ORCID: https://orcid.org/0000-0001-9200-2799)
- Wang-Seob Shim (ORCID: https://orcid.org/0000-0002-0903-1386)
- Kyung‐Tae Lee (ORCID: https://orcid.org/0000-0002-3141-3727)
- Susanna Joo (ORCID: https://orcid.org/0000-0003-0304-8459)
- Su-Hyun Lee (ORCID: https://orcid.org/0000-0001-8481-4367)
- Sung‐Soo Park (ORCID: https://orcid.org/0000-0002-8826-4136)
- Hyeonsu Kim (ORCID: https://orcid.org/0009-0003-4696-9546)
- Beomjin Shin
- Seok Jun Park (ORCID: https://orcid.org/0009-0008-7087-4914)
- Young-Hee Jung
Institutions
- Kyung Hee University (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-10-19
- DOI
- https://doi.org/10.3390/pharmaceutics16101340
- Citations
- 4
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Kyung Hee University
- Ministry of Food and Drug Safety