Novel Deep Sea Isoindole Alkaloid FGFC1 Exhibits Its Fibrinolytic Effects by Inhibiting Thrombin-Activatable Fibrinolysis Inhibitor
From the above findings, FGFC1 is identified as a novel dual-target bioactive compound participating in blood formation/dissolution that demonstrates anti-coagulation and fibrinolytic effects by regulating TAFI activation, inhibiting TAFIa-fibrin combination, and initiating proteolysis. It also provided convincing evidence that TAFI plays a critical role in thrombolysis as a molecular link between coagulation and fibrinolysis. Furthermore, the application of FGFC1 was indicated as a potential therapeutic strategy in thromboembolic and hemorrhagic diseases.
Authors
- Wenhui Wu (ORCID: https://orcid.org/0000-0002-1710-8582)
- Chunde Bao
- Tingting Jiang (ORCID: https://orcid.org/0000-0001-8755-2147)
- Haixing Zhang
- Xiaozhen Diao (ORCID: https://orcid.org/0000-0003-1805-5408)
- Jingjing Shen (ORCID: https://orcid.org/0000-0003-2811-8994)
- Mingjun Wei (ORCID: https://orcid.org/0000-0002-6508-1476)
- Yue Su
Institutions
- Shanghai Jiao Tong University (CN)
- Shimadzu (China) (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-10-20
- DOI
- https://doi.org/10.3390/ph17101401
- Citations
- 1
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China