Inhibitory Effect of Luteolin on Spike S1 Glycoprotein-Induced Inflammation in THP-1 Cells via the ER Stress-Inducing Calcium/CHOP/MAPK Pathway
The results from this study elucidate the mechanisms by which the spike S1 induces inflammation in THP-1 cells and supports the use of naturally occurring bioactive compounds, like luteolin, against inflammation-related SARS-CoV-2 infection.
Authors
- Punnida Arjsri (ORCID: https://orcid.org/0000-0001-6249-4497)
- Pilaiporn Thippraphan
- Sivamoke Dissook (ORCID: https://orcid.org/0000-0002-0695-6682)
- Kamonwan Srisawad (ORCID: https://orcid.org/0000-0002-0260-7215)
- Sonthaya Umsumarng (ORCID: https://orcid.org/0000-0002-0275-1188)
- Patcharawadee Thongkumkoon (ORCID: https://orcid.org/0000-0002-5392-9062)
- Pornngarm Limtrakul (ORCID: https://orcid.org/0000-0001-8732-8911)
- Apiwat Sangphukieo (ORCID: https://orcid.org/0000-0001-5210-5398)
Institutions
- Chiang Mai University (TH)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-10-20
- DOI
- https://doi.org/10.3390/ph17101402
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Chiang Mai University
- Faculty of Medicine, Chiang Mai University