Investigation of Long-Term CD4+ T Cell Receptor Repertoire Changes Following SARS-CoV-2 Infection in Patients with Different Severities of Disease
Our findings suggest advantageous and disadvantageous TCR repertoire patterns in relation to disease severity. Following validation in larger cohorts, our methodology may be useful in detecting protective immunity and the assessment of long-term outcomes, particularly as we begin to unravel the immunological mechanisms leading to post-COVID complications.
Authors
- Kirsty Challen (ORCID: https://orcid.org/0000-0003-4032-5531)
- Jemma Victoria Taylor (ORCID: https://orcid.org/0000-0001-5106-2875)
- Anthony W. Rowbottom (ORCID: https://orcid.org/0000-0002-9861-5892)
- Camilo L. M. Morais (ORCID: https://orcid.org/0000-0003-2573-787X)
- Emma L. Callery (ORCID: https://orcid.org/0000-0003-0786-9182)
Institutions
- Lancashire Teaching Hospitals NHS Foundation Trust (GB)
- University of Lancashire (GB)
- Universidade Federal do Rio Grande do Norte (BR)
Publication Details
- Journal
- Diagnostics
- Published
- 2024-10-19
- DOI
- https://doi.org/10.3390/diagnostics14202330
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Central Lancashire
- Health and Care Research Wales
- National Institute for Health and Care Research