miR-374 family is a key regulator of chronic primary pain onset
Downregulation of miR-374 occurs between adrenergic receptor activation and mechanical hypersensitivity, and its adipocyte source implicates adipose signaling in nociception. Further study of miR-374 may inform therapeutic strategies for the millions worldwide who experience CPPCs.
Authors
- Luda Diatchenko (ORCID: https://orcid.org/0000-0002-1350-6727)
- Nathaniel Hernandez (ORCID: https://orcid.org/0000-0002-3729-4095)
- Francesca Montagna (ORCID: https://orcid.org/0000-0002-2204-0279)
- Yaomin Wang (ORCID: https://orcid.org/0009-0005-2182-7407)
- Hong Dang (ORCID: https://orcid.org/0000-0002-7305-4208)
- Samuel A. McLean (ORCID: https://orcid.org/0000-0001-9482-3582)
- Carolina B. Meloto (ORCID: https://orcid.org/0000-0002-9085-2391)
- Sarah D. Linnstaedt (ORCID: https://orcid.org/0000-0001-5295-7072)
- Andrea G. Nackley (ORCID: https://orcid.org/0000-0003-3688-2271)
- Jiegen Chen
- Ashleigh Rawls
- Mohamad Karaky (ORCID: https://orcid.org/0000-0002-6492-9973)
- Marc Parisien (ORCID: https://orcid.org/0000-0003-2924-5960)
- Xin Zhang (ORCID: https://orcid.org/0000-0003-2675-8197)
- Yue Pan (ORCID: https://orcid.org/0000-0003-1958-2744)
- Xianglong Gao (ORCID: https://orcid.org/0009-0003-7810-5494)
- Ying Zhao (ORCID: https://orcid.org/0009-0009-5182-8100)
Institutions
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- McGill University Health Centre (CA)
- Lung Institute (US)
Publication Details
- Journal
- PAIN Reports
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1097/pr9.0000000000001199
- Citations
- 2
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of General Medical Sciences
- National Institute of Neurological Disorders and Stroke
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of Dental and Craniofacial Research