Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma
Collectively, our data support a rationale for localized olaparib delivery concomitant with the current clinical regimen for malignant glioma treatment.
Authors
- Betty Tyler (ORCID: https://orcid.org/0000-0001-9800-6969)
- Phoebe McCrorie
- Ian Suk
- Kevin M. Shakesheff (ORCID: https://orcid.org/0000-0003-3236-2439)
- Cara Moloney (ORCID: https://orcid.org/0000-0002-2230-6612)
- Philip Berry (ORCID: https://orcid.org/0000-0003-0104-4737)
- Henry Brem (ORCID: https://orcid.org/0000-0001-7539-4786)
- Ruman Rahman (ORCID: https://orcid.org/0000-0002-6541-9983)
- Noah Gorelick (ORCID: https://orcid.org/0000-0003-1313-1061)
- Richard Guy Grundy (ORCID: https://orcid.org/0000-0002-2585-2539)
- Jonathan Rowlinson (ORCID: https://orcid.org/0000-0002-2727-3215)
- Anthony J. Chalmers (ORCID: https://orcid.org/0000-0002-1746-7278)
- Stuart Smith (ORCID: https://orcid.org/0000-0002-4556-2707)
- Gareth J. Veal (ORCID: https://orcid.org/0000-0002-1897-8678)
- Cameron Alexander (ORCID: https://orcid.org/0000-0001-8337-1875)
- Riccardo Serra (ORCID: https://orcid.org/0000-0002-1975-393X)
Institutions
- University of Nottingham (GB)
- Johns Hopkins University (US)
- The Open University (GB)
- Johns Hopkins Medicine (US)
- Brain Tumour Research (GB)
- University of Glasgow (GB)
- Newcastle University (GB)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1038/s41416-024-02878-2
- Citations
- 6
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.70