Host cytokine genetic polymorphisms in a selected population of persons living with hepatitis B virus infection in the central region of Ghana
In conclusion, variations in IL2 rs1479920 GG and IL2 rs1479921 AA could offer protective effects by reducing HBV DNA. TNF-α rs179924CT may also cause elevation in HBV DNA levels whiles TNF-α -308A/G, showed a potential protective effect on liver scarring in HBV infected participants. It is therefore important to take a further look at such variations for understanding of HBV modulation in the Ghanaian population.
Authors
- Faustina Adu
- Akwasi Anyanful
- Samuel Badu Nyarko (ORCID: https://orcid.org/0000-0003-1104-7544)
- Nicholas Ekow Thomford (ORCID: https://orcid.org/0000-0002-3152-5817)
- Ebenezer Aniakwaa-Bonsu
- Richmond Owusu Ateko
- Aikins Sarpong Obeng
Institutions
- University of Cape Coast (GH)
- University of Ghana (GH)
- University of Cape Town (ZA)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s12876-024-03456-9
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation