The effect of modulating platelet reactive oxygen species by the addition of antioxidants to prevent clearance of cold-stored platelets
This study demonstrated correlations between reactive oxygen species production and their pro-oxidant effects on platelet clearance after cold storage. The addition of N-acetylcysteine at an appropriate concentration do not only protects chilled platelets from storage lesions caused by reactive oxygen species overproduction but also prevents platelet phagocytosis in vitro and clearance in vivo, thereby extending circulating time.
Authors
- Juan Sun (ORCID: https://orcid.org/0000-0001-6352-0589)
- Jie Yang (ORCID: https://orcid.org/0000-0003-3031-0504)
- Yiming Yang
- Rufeng Xie (ORCID: https://orcid.org/0000-0002-6900-7417)
- Xueyu Jiang
- Li Gao (ORCID: https://orcid.org/0000-0002-5757-2830)
Institutions
- Shanghai Blood Center (CN)
Publication Details
- Journal
- Hematology Transfusion and Cell Therapy
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.htct.2024.09.2479
- Citations
- 3
- Primary Topic
- Intramuscular injections and effects
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- Shanghai Municipal Health Commission
- Fudan University
- Huashan Hospital
- Shanghai Medical College, Fudan University