Preventive efficacy of hydrocortisone enema for radiation proctitis in rectal cancer patients undergoing short-course radiotherapy: a phase II randomized placebo-controlled clinical trial
Hydrocortisone enema was associated with a significant reduction in the severity of proctitis, diarrhea, and rectal pain compared to placebo. Additionally, patients treated with hydrocortisone experienced shorter durations of gastrointestinal toxicity following SCRT. This study highlights the potential benefits of hydrocortisone enema in managing radiation-induced toxicity in rectal cancer patients undergoing radiotherapy.
Authors
- Mansour Ansari (ORCID: https://orcid.org/0000-0002-8249-1776)
- Behnam Kadkhodaei (ORCID: https://orcid.org/0000-0003-3479-9239)
- Nam P. Nguyen (ORCID: https://orcid.org/0000-0001-5106-6665)
- Maryam Tazang (ORCID: https://orcid.org/0009-0004-0266-1723)
- Μohammad Mohammadianpanah (ORCID: https://orcid.org/0000-0001-9391-8977)
- Niloofar Ahmadloo (ORCID: https://orcid.org/0000-0001-5203-3398)
- Seyed Vahid Hosseini (ORCID: https://orcid.org/0000-0002-9228-3567)
- Nezhat Khanjani (ORCID: https://orcid.org/0000-0002-0717-4631)
- Hamid Nasrollahi (ORCID: https://orcid.org/0000-0002-7423-3312)
- Shapour Omidvari (ORCID: https://orcid.org/0000-0003-3656-9891)
- Ahmad Mosalaei (ORCID: https://orcid.org/0000-0002-3986-8865)
Institutions
- Howard University (US)
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- Annals of Coloproctology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.3393/ac.2024.00192.0027
- Citations
- 1
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Shiraz University of Medical Sciences
- Shiraz University