Mitochondrial FIS1 As a Novel Drug Target for the Treatment of Erectile Dysfunction: A Multi-Omic and Epigenomic Association Study
This study demonstrated the causal relationship between the mitochondrial <i>FIS1</i> gene and ED risk and found that resveratrol and quercetin may have therapeutic effects on ED. These discoveries offer fresh perspectives on the pathogenesis of ED and propose preliminary candidate targets and drugs for future treatment of ED.
Authors
- Jingjing Gao (ORCID: https://orcid.org/0000-0003-4226-3944)
- Junhua Du
- Tianle Zhu (ORCID: https://orcid.org/0000-0002-2816-0175)
- Xiansheng Zhang (ORCID: https://orcid.org/0000-0001-6003-5182)
- Hui Jiang (ORCID: https://orcid.org/0000-0002-6256-2733)
- Yukuai Ma (ORCID: https://orcid.org/0009-0000-8479-6779)
- Pan Gao (ORCID: https://orcid.org/0000-0003-0973-7845)
- Peng Yang (ORCID: https://orcid.org/0009-0005-3739-5047)
- Z.P. Cao (ORCID: https://orcid.org/0009-0007-0426-4643)
Institutions
- Anhui Medical University (CN)
- Peking University (CN)
- Peking University First Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- The World Journal of Men s Health
- Published
- 2024-10-22
- DOI
- https://doi.org/10.5534/wjmh.240131
- Citations
- 5
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China
- University Natural Science Research Project of Anhui Province