ACE and ACE2 activities and polymorphisms assessment: A populational study from Ipaussu (SP, Brazil) during the COVID-19 pandemic
For the first time, it was demonstrated that in females, the GG genotype is associated with increased ACE activity ratio (Z-FHL/h-HL) in the COVID-19-positive group. Elevated ACE activity ratio (Z-FHL/h-HL) is highly linked to inflammation and may justify the associations between the G genotype and COVID-19 severity of symptoms and outcomes.
Authors
- Dulce Elena Casarini (ORCID: https://orcid.org/0000-0003-1912-4292)
- Lilian Caroline Gonçalves de Oliveira (ORCID: https://orcid.org/0000-0001-5117-6979)
- Hélio Tedesco‐Silva (ORCID: https://orcid.org/0000-0002-9896-323X)
- Andréia Cristina Febba Gomes
- Nayara Azinheira Nobrega Cruz (ORCID: https://orcid.org/0000-0002-9689-9545)
- Jose Osmar Medina-Pestana (ORCID: https://orcid.org/0000-0002-0750-7360)
- Marcos Antônio Cenedeze (ORCID: https://orcid.org/0000-0002-8878-6268)
- Lilian dos Santos
- Lys Angela Favaroni Mendes Salgado Ribeiro
Institutions
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1016/j.lfs.2024.123157
- Citations
- 1
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo