Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies

Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.

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Publication Details

Journal
Pain
Published
2024-10-16
DOI
https://doi.org/10.1097/j.pain.0000000000003445
Citations
9
Primary Topic
Pain Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
2.94

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article

Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies

Margarita Calvo, Claudia Sommer, David Bennett, Eske Kvanner Aasvang et al.
9 citations
Pain
Pain Mechanisms and Treatments
2.94
article

Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies

Margarita Calvo, Claudia Sommer, David Bennett, Eske Kvanner Aasvang, Jannis Körner, Andrea Truini, Rolf‐Detlef Treede, Ralf Baron, James R.F. Hockley, Theodore J. Price, Nanna Brix Finnerup, Harriet I. Kemp, Ekaterina Kutafina, Annina B. Schmid, Zahra Nochi, Angelika Lampert, Nadine Attal, Emmanuel Bourinet, Nurcan Üçeyler, Andreas C. Themistocleous, Franziska Denk, Sara García-de-Villa, Páll Karlsson, Andrew S.C. Rice, Eleonora Galosi, Pille Taba, Margarita Mürk
article en
9 citations

Abstract

Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.

PainVol. 166(5)
Centre National de la Recherche Scientifique (FR), Apple (Israel) (IL), Inserm (FR), Pontificia Universidad Católica de Chile (CL), The University of Texas at Dallas (US), University of Cologne (DE), King's College London (GB), Université de Versailles Saint-Quentin-en-Yvelines (FR), Université de Montpellier (FR), Aarhus University (DK), Heidelberg University (DE), Age UK (GB), University Hospital Heidelberg (DE), Tartu University Hospital (EE), Copenhagen University Hospital (DK), Rigshospitalet (DK), Christian-Albrechts-Universität zu Kiel (DE), University of Oxford (GB), Assistance Publique – Hôpitaux de Paris (FR), Central Institute of Mental Health (DE), Universitätsklinikum Aachen (DE), Universitätsklinikum Würzburg (DE), Hôpital Ambroise-Paré (FR), Danish Pain Research Center (DK), University Hospital Cologne (DE), Institut de Génomique Fonctionnelle (FR), Imperial College London (GB), University of Tartu (EE), Sapienza University of Rome (IT), RWTH Aachen University (DE)
European Commission, Deutsche Forschungsgemeinschaft
Partnerships for the goals
Openalex Percentile: Top 8%
Pain Mechanisms and Treatments
2.94
DOIOpen Access PDFOpenAlex
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